EFFECTS OF PSORALEN-DERIVATIZED OLIGONUCLEOSIDE METHYLPHOSPHONATES ONVESICULAR STOMATITIS-VIRUS (VSV) PROTEIN-SYNTHESIS IN-VITRO AND IN VSV-INFECTED CELLS

Authors
LEVIS JT KEAN JM MILLER PS
Citation
Jt. Levis et al., EFFECTS OF PSORALEN-DERIVATIZED OLIGONUCLEOSIDE METHYLPHOSPHONATES ONVESICULAR STOMATITIS-VIRUS (VSV) PROTEIN-SYNTHESIS IN-VITRO AND IN VSV-INFECTED CELLS, Nucleosides & nucleotides, 15(1-3), 1996, pp. 539-557
Citations number
28
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
15
Issue
1-3
Year of publication
1996
Pages
539 - 557
Database
ISI
SICI code
0732-8311(1996)15:1-3<539:EOPOMO>2.0.ZU;2-A
Abstract
Oligodeoxyribonucleoside methylphosphonates (16-mers) targeted to VSV mRNAs were derivatized with (aminoethyl)amino]methyl}-4,5'8-trimethylp soralen. These oligomers specifically inhibit translation of their tar geted mRNAs in vitro following UV irradiation of the oligomer-mRNA com plexes. Psoralen-derivatized oligonucleoside methylphosphonates are st able in cells and can inhibit VSV protein synthesis in culture followi ng UV-irradiation of VSV-infected cells.