SYNTHESIS OF L-HISTIDINE AND (-)-SPINACINE CHITOOLIGOSYL AMIDES

Authors
LEY JP PETER MG
Citation
Jp. Ley et Mg. Peter, SYNTHESIS OF L-HISTIDINE AND (-)-SPINACINE CHITOOLIGOSYL AMIDES, Journal of carbohydrate chemistry, 15(1), 1996, pp. 51-64
Citations number
32
Categorie Soggetti
Chemistry Inorganic & Nuclear",Biology
Journal title
Journal of carbohydrate chemistry → ACNP
ISSN journal
07328303
Volume
15
Issue
1
Year of publication
1996
Pages
51 - 64
Database
ISI
SICI code
0732-8303(1996)15:1<51:SOLA(C>2.0.ZU;2-C
Abstract
The synthesis of etamido-4-O-[2-acetamido-4-O-{2-acetamido-2-deoxy- an osyl]-2-deoxy-beta-D-glucopyranosyl)-L-histidine amide (3), ,6,7-tetra hydroimidazo[4,5-c]pyridine-6-carboxylic amide (4) and 6,7-tetrahydroi midazo[4,5-c]pyridine-6-carboxamide (5) is achieved via coupling of th e appropiate glycosylamines with Boc-protected L-histidine or with ,6, 7-tetrahydroimidazo[4,5-c]pyridine-6-carboxylic acid ((-)-spinacine), respectively, by means of EEDQ and subsequent deprotection.