NEW APPROACH TO THE SYNTHESIS OF OLIGO(NUCLEOSIDE METHANEPHOSPHONATE)S

Authors
WOZNIAK L PYZOWSKI J STEC WJ
Citation
L. Wozniak et al., NEW APPROACH TO THE SYNTHESIS OF OLIGO(NUCLEOSIDE METHANEPHOSPHONATE)S, Journal of organic chemistry, 61(3), 1996, pp. 879-881
Citations number
19
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of organic chemistry → ACNP
ISSN journal
00223263
Volume
61
Issue
3
Year of publication
1996
Pages
879 - 881
Database
ISI
SICI code
0022-3263(1996)61:3<879:NATTSO>2.0.ZU;2-B
Abstract
new method of preparation of 5'-O-DMT-(N-protected) nucleoside 3'-O-(m ethanephosphonofluoridates) 2 and their phosphonylating properties tow ard alcohols, in particular the 5'-hydroxyl groups of nucleosides (or nucleotides), is presented. Preparation of dinucleoside (3',5')-methan ephosphonates 3 in solution and solid-phase synthesis of Me-Oligo 6 de monstrate the potential use of 2 as monomers.