The case history of a 20-year-old male patient who sustained an 85 per
cent total body surface area alkali burn to his skin, after falling i
nto a caustic lime pit, is reported. Considerable problems regarding t
he correct estimate of burn wound depth, predominant location of the d
eepest burn on the posterior half of the body, appropriate wound cover
age, and lack of sufficient skin graft donor sites required a complex
treatment plan. Excisions to fascia and intradermal debridement were r
equired to achieve an appropriate bed for wound closure. Five per cent
mafenide acetate solution (Sulfamylon) was applied to prevent burn wo
und sepsis. Human allografts and Biobrane were used extensively to ach
ieve temporary wound closure, to provide mechanical protection of fres
hly autografted wounds, and to prevent desiccation following applicati
on of cultured epidermal autografts on to debrided wounds and split th
ickness skin grafted donor sites. The case illustrates a number of pro
blems associated with the evaluation and treatment of patients sufferi
ng severe alkali burns and demonstrates the implementation of both est
ablished and evolving technologies in the management of these injuries
.