Exposure of the skin to nitrous oxide, a liquified gas stored under pr
essure in a cylinder, can occur in anaesthesiologists and in those inv
olved in recreational misuse of the gas. A case is reported of a man w
ho presented to the emergency department after sniffing nitrous oxide
and sustaining frostbite injury to his left cheek. Conservative manage
ment of this injury allowed spontaneous separation of the necrotic tis
sue and healing of the granulating wound by contraction.