The goal of placement of endosseous dental implants is to achieve osse
ointegration or biointegration of the bone with the implant. A wide va
riety of materials has been used for these implants, but only a few pr
omote osseointegration and biointegration. Titanium and titanium alloy
(Ti6Al4V) have been the most widely used of these materials. The surf
ace oxide of titanium appears to be central to the ability of this mat
erial to osseointegrate. The oxide limits dissolution of elements and
promotes the deposition of biological molecules which allow bone to ex
ist as close as 30 Angstrom to the surface of the implant. The details
of the ultrastructure of the gap between the implant and bone remain
undefined, and the consequences of elements which are released on the
interface over time are not known. These areas of investigation are pa
rticularly important in defining the differences between commercially
pure titanium implants and those made of titanium, aluminium and vanad
ium. The epithelial interface between the gingiva and titanium appears
to contain many of the structural characteristics of the native tooth
-gingiva interface, but details are still vague. The connective tissue
interface with the titanium appears to be one of tightly fitting tiss
ues rather than adhesion. Ceramic coatings appear to improve the ingro
wth of bone and promote chemical integration of the implant with the b
one. The characteristics of these coatings are complex and affect the
bony response, but the mechanisms remain obscure. The degradation of t
he coatings is an issue of particular controversy. Progress in dental
implantology is likely to continue as the interface between the materi
al and bone is more clearly understood, and biological molecules and a
rtificial tissues are developed.