The comet-tail artifact is commonly encountered in a variety of clinic
al conditions; however, its presence and significance in a thyroid nod
ule has not been documented before. We document its presence in 100 pa
tients who underwent ultrasound examinations of the neck and thyroid.
None of the thyroid nodules showed any evidence of malignancy on repea
ted fine-needle aspiration cytology (FNAC). In 85% of patients with th
e artifact, abundant colloid was seen on FNAC, suggesting that the art
ifact may be related to the presence of colloid. Four different patter
ns of distribution of the artifact within the nodule were noted and th
ese helped to determine the size of the needle to be used for a succes
sful aspiration. (C) 1996 John Wiley & Sons, Inc.