CYCLOSPORINE-INDUCED TRANSIENT RENAL HYPOPERFUSION IN ADOLESCENT TRANSPLANT RECIPIENTS

We investigated the acute hemodynamic effect of a single oral dose of cyclosporine A (CsA) given as part of the immunosuppressive schedule i n six adolescents with renal transplants. Renal plasma flow (RPF) and glomerular filtration rate (GFR) were determined by continuous infusio n of inulin and amino-hippuric acid for 12 h. A fall in both GFR and R PF was observed 4-6 h after peak plasma CsA levels. No significant cor relation was found with CsA dosage or any pharmacokinetic parameters. This study demonstrates that CsA also has a vasoconstrictory effect in adolescent recipients; this could be one of the causes of its nephrot oxicity.