ISOLATION AND MAPPING OF A NOVEL HUMAN GENE ENCODING A PROTEIN CONTAINING ZINC-FINGER STRUCTURES

We have isolated and characterized a cDNA clone, termed OTK18, represe nting a novel human gene. The 3754 nucleotides of this clone contain a n open reading frame of 2133 nucleotides. As the predicted 711-amino-a cid protein contains 13 contiguous zinc-finger structures of the C2H2 type, it would be expected to function as a DNA-binding multi-finger p rotein. The 4.3-kb transcript was expressed in all adult human tissues examined by Northern analysis. The gene was assigned to chromosomal b and 19q13.4 by fluorescence in situ hybridization. (C) 1996 Academic P ress Inc.