LOCALIZATION OF 2 POTASSIUM CHANNEL BETA-SUBUNIT GENES, KCNA1B AND KCNA2B

The gating properties and current amplitudes of mammalian voltage-acti vated Shaker potassium channels are modulated by at least two associat ed beta subunits (KV beta 1.1 and KV beta 1.B). The human Kv beta 1.1 gene (KCNA1B) resides on chromosome 3, as indicated by somatic cell hy brid mapping. More precise localization of KCNA1B to 3q26.1 was obtain ed with fluorescence in situ hybridization (FISH) and was corroborated by PCR screening of the CEPH YAC library. The human Kv beta 1.2 gene (KCNA2B) resides on chromosome 1, as indicated by somatic cell hybrid mapping, and has been localized by FISH to 1p36.3. (C) 1996 Academic P ress, Inc.