SYNTHESIS AND TUMORINHIBITING ACTIVITY OF LANTHANUM(III) COMPLEXES WITH SOME 1-AMINOCYCLOALKANCARBOXYLIC ACIDS

Complexes of La(III) with 1-aminocyclopentane-, -hexane, -heptane and -4-ethylcyclohexanecarboxylic acids were obtained. The compounds were characterized by elemental analyses, IR spectroscopy and conductivity measurements. The following general formula was derived: LaL(3)Cl(3) . 5 H2O, where L is the corresponding 1-aminocycloalkanecarboxylic acid . The pharmacological studies showed that all complexes manifested hig her cytostatic and cytotoxic effects in comparison with lanthanum chlo ride. Much higher cytotoxic (anti-P388/D1) and cytostatic (anti-L-1210 and antimelanoma-B16) activity was found for the lanthanum complex wi th 1-aminocyclopentanecarboxylic acid.