LIPID-PEROXIDATION DURING ACUTE STRESS

Lipid peroxidation (LPO) is one of the main events induced by oxidativ e stress. The aim of our study was to investigate the influence of 30 min cold-immobilization (model of acute stress used in this experiment ) on LPO in the brain, heart, liver and stomach homogenates of the rat s. LPO was determined by measuring of the contents of thiobarbituric a cid reactive substances (TEARS), conjugated dienes (CD) and sulfhydryl groups (SH). Experimental stress induced inhancement of TEARS formati on in the liver and increased level of the CD in the heart, stomach an d liver, while in the brain both parameters were found to be decreased . The levels of TEARS were not changed in the heart and in the stomach , too. The concentrations of SH-groups were decreased in the heart, br ain and stomach, while in the liver the parameter was found to be not changed. The results of this study showed the increase of LPO in the h eart, stomach and liver under stress conditions. It could be supposed that LPO may be involved in mechanisms of stress injury in different t issues.