Melkersson-Rosenthal syndrome is characterized by facial or lip edema,
peripheral facial palsy and scrotal tongue. We report three patients
with the syndrome. A 17 years old male had malar and superior lip enla
rgement that coincided with a peripheral facial palsy. A 40 years old
male with recurrent facial palsy presented with episodes of contralate
ral facial enlargement. A 32 years old female consulted for a hypertro
phy of labia minora and majora and facial infiltration. Biopsies showe
d a granulomatous cheilitis in all cases. Two patients were treated wi
th clofazimine with partial results. The female patient did not accept
plastic surgery.