LONG-TERM EFFICACY OF A NEW FORMULATION OF PROSTAGLANDIN-E1 AS TREATMENT FOR ERECTILE FAILURE

Purpose: We determined the long-term efficacy of intracavernous inject ion of a new formulation of prostaglandin E1 (Caverject) as treatment for erectile failure. Materials and Methods: A prospective study was done at a university affiliated Veterans Affairs medical center. Subje cts with erectile failure received injections of prostaglandin E1 at t he office and self-administered injections at home for up to 18 months . Results: Of 16 patients who performed home injections 15 completed 6 months and 10 completed 18 months of therapy. Patient and spousal sat isfaction with intercourse was 90% for months 1 to 6, and patient sati sfaction was 95% for months 7 to 18. Conclusions: Prostaglandin E1 was highly effective at producing penile rigidity and an erection with sa tisfactory vaginal intercourse.