EVIDENCE FOR A MECHANISTIC ASSOCIATION BETWEEN NONBACTERIAL PROSTATITIS AND LEVELS OF URATE AND CREATININE IN EXPRESSED PROSTATIC SECRETION

Purpose: Chronic prostatitis is a common disease of the late teenage y ears, which affects patients for many years. In the majority of cases etiology is unknown but in some cases prostatitis is clearly caused by microorganisms that result from overuse of antibiotic drugs. We attem pt to gain further knowledge about the etiology of the disease. Materi als and Methods: We studied 56 patients with nonbacterial prostatitis in regard to whether urine reflux into the prostatic ducts was respons ible for increased concentrations of creatinine, urate and white blood cells in expressed prostatic secretion. The patients were interviewed using a standard questionnaire. Results: A relationship was demonstra ted between pain estimated in accordance with a scoring scale, and exp ressed prostatic secretion contents of white blood cells, urate and cr eatinine, Conclusions: These results provide further support of the ro le of reflux into the prostatic ducts as an underlying mechanism initi ating a chemical inflammatory reaction. Urate appears to be the chemic al. agent eliciting this inflammatory response.