COMPARISON OF THE EFFICACY OF INTRAUTERINE DICLOFENAC AND IBUPROFEN PELLETS AS ADJUVANTS TO QUINACRINE NONSURGICAL FEMALE STERILIZATION

To investigate relative efficacy of intrauterine diclofenac and ibupro fen as adjuvants to intrauterine quinacrine for nonsurgical sterilizat ion, a total of 900 women were systematically allocated to 2 monthly i nsertions of pellets of diclofenac (75 mg) or ibuprofen (55.5 mg) as a djuvants to intrauterine quinacrine (216 mg) in a rural private practi ce in West Bengal, India. All women were prescribed oral contraceptive s for three months from first insertion. In the middle of the study in creased care was taken to insert pellets at the fundus. There was no s tatistically significant difference found in cumulative life-table pre gnancy failure rates at 36 months for women receiving diclofenac (2.7 +/- 0.82) or ibuprofen (3.4 +/- 0.89). Taking care to insert pellets a t the fundus resulted in a decline of failures at 24 months from 4.4 /- 0.92 to zero. Intrauterine administration of pellets of quinacrine (216 mg) plus diclofenac (75 mg) or ibuprofen (55.5 mg) with 3 months' oral contraception provides acceptable efficacy if pellets are insert ed to the fundus.