We report a 69-yr-old female,vith a liver mass which, when surgically
resected, was believed to be the spontaneous complete necrosis of hepa
tocellular carcinoma, The preoperative level of alpha-fetoprotein was
high at 1050 ng/ml, and the mass was grossly an encapsulated nodular l
esion with septa, Histologically, no viable tumor cells were demonstra
ted. The alpha-fetoprotein level decreased to a normal range, The post
operative course was uneventful, and the patient is alive and well 1 y
r after surgery.