INFLUENCE OF BODY-WEIGHT CHANGES ON THE R ATE OF POSTMENOPAUSAL BONE LOSS

Citation
Jm. Pouilles et al., INFLUENCE OF BODY-WEIGHT CHANGES ON THE R ATE OF POSTMENOPAUSAL BONE LOSS, Annales d'Endocrinologie, 56(6), 1995, pp. 585-589
Citations number
21
Categorie Soggetti
Endocrynology & Metabolism
Journal title
ISSN journal
00034266
Volume
56
Issue
6
Year of publication
1995
Pages
585 - 589
Database
ISI
SICI code
0003-4266(1995)56:6<585:IOBCOT>2.0.ZU;2-R
Abstract
Numerous data suggest, at any age, a clear relationship between body w eight and Bone Mineral Density (BMD). On the other hand, the effects o f individual changes in body weight on BMD are still poorly understood . Fourty four normal women of normal weight, who had passed a natural menopause 6 months to 5 years earlier, were followed during a mean per iod of lime of 40 months. They all underwent three BMD measurements by Dual X-Ray Absorptiometry and a clinical examination. There was a sig nificant correlation (p < 0.05) between the changes in weight and the changes in BMD at the vertebral (r = 0.31) and femoral (r = 0.30) leve ls. This association remained significant after adjustment for physica l characteristics, age, years since menopause and initial BMD values. Moreover, the subgroup of women who gained more than one kilogram duri ng the followup had a rate of bone loss which was about twice less tha n that in the rest of the group. This longitudinal study shows that ch anges in body weight are able to influence the rate of postmenopausal bone loss through mechanisms that are still discussed.