PROTEIN-FOLDING DYNAMICS - APPLICATION OF THE DIFFUSION-COLLISION MODEL TO THE FOLDING OF A 4-HELIX BUNDLE

Authors
YAPA KK WEAVER DL
Citation
Kk. Yapa et Dl. Weaver, PROTEIN-FOLDING DYNAMICS - APPLICATION OF THE DIFFUSION-COLLISION MODEL TO THE FOLDING OF A 4-HELIX BUNDLE, Journal of physical chemistry, 100(7), 1996, pp. 2498-2509
Citations number
46
Categorie Soggetti
Chemistry Physical
Journal title
Journal of physical chemistry → ACNP
ISSN journal
00223654
Volume
100
Issue
7
Year of publication
1996
Pages
2498 - 2509
Database
ISI
SICI code
0022-3654(1996)100:7<2498:PD-AOT>2.0.ZU;2-O
Abstract
A de novo designed four-helix bundle polypeptide with a modeled three- dimensional structure has been studied by chemical kinetics and Browni an dynamics simulations as an application of the diffusion-collision m odel. The complementary studies give information on kinetic pathways i n the folding of the peptide and on the statistical propensities and t ime histories of the positions and orientations of the four helices.