A new two-stage approach for nonlinear brain image registration is pro
posed, In the first stage, an active contour algorithm is used to esta
blish a homothetic one-to-one map between a set of region boundaries i
n two images to he registered. This mapping is used in the second step
: a two-dimensional transformation which is based on an elastic body d
eformation, This method is tested by registering magnetic resonance im
ages to atlas images.