REGIONAL LOCALIZATION OF RAT AND MOUSE PROTEIN-TYROSINE-PHOSPHATASE PTP-ALPHA LRP GENE (PTPRA) BY FLUORESCENCE IN-SITU HYBRIDIZATION/

Protein tyrosine phosphatases (PTPases) negatively regulate the effect (s) of protein tyrosine kinases and are implicated in the regulation o f a variety of biological events including cell activation, differenti ation, and neoplastic transformation. To gain insight into the role(s) of the PTPases, we mapped the gene encoding for the widely expressed receptor-like protein tyrosine phosphatase PTPa/LRP (locus symbol Ptpr a) to rat chromosome 3q36 and mouse chromosome 2G by fluorescence in s itu hybridization method. These results indicate that there is a conse rved syntenic group between human 20p13, rat 3q36, and mouse 2G.