CONFLUENT AND RETICULATED PAPILLOMATOSIS - RESPONSE TO MINOCYCLINE

Background: Confluent and reticulated papillomatosis (CRP) of Gougerot and Carteaud is an uncommon disorder of unknown cause for which a var iety of treatments have been proposed. Objective: We attempted to eval uate the effectiveness of oral minocycline. Methods: Nine patients wit h CRP were treated with oral minocycline, 50 mg twice a day, for 6 wee ks. The average follow-up period was 11 months. Recurrence rate, side effects, and effectiveness of therapy were assessed. Results: All pati ents except two had a 90% to 100% response to therapy. Recurrences wer e noted in three patients, all of whom responded to re-treatment with minocycline. None of the nine patients had an adverse reaction. Conclu sion: Minocycline, 50 mg twice a day, is safe and effective for CRP.