STRUCTURE-ANALYSIS OF MONOAMINE-OXIDASE INHIBITORS, HYDROXYMETHYL-3-(4-METHOXYPHENYL)-OXAZOLIDIN-2-ONE AND METHOXYMETHYL-3-(4-METHOXYPHENYL)-OXAZOLIDIN-2-ONE

Authors
WOUTERS J PERPETE P NORBERG B EVRARD G DURANT F
Citation
J. Wouters et al., STRUCTURE-ANALYSIS OF MONOAMINE-OXIDASE INHIBITORS, HYDROXYMETHYL-3-(4-METHOXYPHENYL)-OXAZOLIDIN-2-ONE AND METHOXYMETHYL-3-(4-METHOXYPHENYL)-OXAZOLIDIN-2-ONE, Acta crystallographica. Section C, Crystal structure communications, 50, 1994, pp. 97-100
Citations number
7
Categorie Soggetti
Crystallography
Journal title
Acta crystallographica. Section C, Crystal structure communications → ACNP
ISSN journal
01082701
Volume
50
Year of publication
1994
Part
1
Pages
97 - 100
Database
ISI
SICI code
0108-2701(1994)50:<97:SOMIH>2.0.ZU;2-3
Abstract
X-ray single-crystal structures of two recently synthesized inhibitors of monoamine oxidase (MAO) belonging to the aryloxazolidinone family are reported. The first compound is ydroxy-methyl-3-(4-methoxyphenyl)o xazolidin-2-one, C11H13NO4 (1) and the second is ethoxy-methyl-3-(4-me thoxyphenyl)oxazolidin-2-one, C12H15NO4 (11). Both compounds show copl anarity between the phenyl and oxazolidinone rings and electronic delo calization between the heteroatoms of the oxazolidinone moiety as indi cated by the bond lengths. The crystal packing is assumed to be by van der Waals interactions. Cohesion is increased in the structure of (1) by the presence of hydrogen bonds.