SR-48692, A NONPEPTIDE NEUROTENSIN RECEPTOR ANTAGONIST, BLOCKS THE CARDIOVASCULAR EFFECTS ELICITED BY NEUROTENSIN IN GUINEA-PIGS

Authors
NISATO D GUIRAUDOU P BARTHELEMY G GULLY D LEFUR G
Citation
D. Nisato et al., SR-48692, A NONPEPTIDE NEUROTENSIN RECEPTOR ANTAGONIST, BLOCKS THE CARDIOVASCULAR EFFECTS ELICITED BY NEUROTENSIN IN GUINEA-PIGS, Life sciences, 54(7), 1994, pp. 95-100
Citations number
12
Categorie Soggetti
Biology,"Medicine, Research & Experimental","Pharmacology & Pharmacy
Journal title
Life sciences → ACNP
ISSN journal
00243205
Volume
54
Issue
7
Year of publication
1994
Pages
95 - 100
Database
ISI
SICI code
0024-3205(1994)54:7<95:SANNRA>2.0.ZU;2-5
Abstract
In guinea pigs anaesthetized with sodium pentobarbital, SR 48692, a no n peptide neurotensin receptor antagonist blunted the blood pressure i ncrease induced by exogenous neurotensin in a dose dependent manner. F urthermore, in isolated spontaneously beating guinea pig atria, both t he tachycardia and inotropic responses induced by neurotensin were pot ently antagonized. SR 48692 did not show any intrinsic effect in vivo or in vitro.