NOVEL ANTIMICROBIAL COMPOUNDS IDENTIFIED USING SYNTHETIC COMBINATORIAL LIBRARY TECHNOLOGY

The recent emergence of combinatorial chemistry has greatly advanced t he development of biologically active lead compounds. It is anticipate d that combinatorial library technology will add great value to the fi ght against drug-resistant bacterial strains, which pose increasingly serious health hazards, Owing to the need to use complex cell-based as says and, in turn, to screen free compounds in solution, the potential use of combinatorial libraries in the field of infectious diseases ha s not yet been fully explored. Despite these limitations, a number of new antimicrobial and/or antifungal compounds have been successfully i dentified from pools of millions of other compounds.