IN-VITRO ACTIVITY OF IMIPENEM AND 6 OTHER BETA-LACTAM ANTIBIOTICS AGAINST AMINOGLYCOSIDE-RESISTANT GRAM-NEGATIVE BACILLI

The in vitro activity of imipenem and six other beta-lactams (ampicill in, cefamandole, cefoxitin, ceftriaxone, ceftazidime, cefotaxime) agai nst twenty Gramnegative bacilli resistant to clinically important amin oglycosides was studied. The bacterial strains showed high resistance (R) to gentamicin, tobramycin (R 100%), netilmicin (R 75%) and to the beta-lactams ampicillin (R 100%), cephamandole (R 90%) and cefoxitin ( R 75%). The strains were susceptible to isepamicin (R 10%) and imipene m (R 10%) as well as susceptible to at least third generation cephalos porin. Three Pseudomonas aeruginosa strains were resistant to the majo rity of antibiotics, except for imipenem.