Taurine which has antioxidant effects is also known to have effects on
cell proliferation, inflammation and collagenogenesis. The aim of thi
s study was to investigate the effect of taurine on incisional skin wo
unds. The mice incised on the dorsal area were divided into control an
d experimental groups. Saline was injected intraperitoneally to half o
f the animals in the control group and locally applied to the other ha
lf. Fifty mM taurine solution was given intraperitoneally to the first
half of the experimental animals and locally to the second half of th
e experimental group. After four days of treatment, malondialdehyde (M
DA) and histamine levels as well as the tensile strength of the wound
tissue were measured. Structural alterations in epidermis and dermis w
ere histologically evaluated. The locally administreated taurine signi
ficantly increased wound tensile strength by decreasing the MDA and hi
stamine levels and prevented the degranulation of the mast cells. Thes
e observations suggest that taurine may be useful on wound healing.