THE AMPA ANTAGONISTS NBQX AND GYKI-52466 DO NOT COUNTERACT NEUROLEPTIC-INDUCED CATALEPSY

The AMPA antagonists NBQX (2.5, 5, 10 mg/kg) and GYKI 52466 (4.8, 8 mg /kg) were investigated in haloperidol (0.5 mg/kg)-induced catalepsy in the rat. The effects of AMPA antagonists administered either alone or in combination with the noncompetitive NMDA antagonist dizocilpine (0 .02 mg/kg), with the dopamine D-2 agonist quinpirole (1 mg/kg) or with L-DOPA (50, 100 mg/kg plus benserazide) were tested. NBQX or GYKI 524 66 did not exert anticataleptic effects, neither alone nor in combinat ion with dizocilpine, quinpirole or L-DOPA. Thus, in the rat inhibitio n of AMPA receptors with NBQX or GYKI 52466 does not have effects pred ictive for an antiparkinsonian potential.