This paper reviews the theory of partial -algebras of closable operat
ors in Hilbert space (partial O-algebras), with some emphasis on part
ial GW-algebras. First we discuss the general properties and the vari
ous types of partial -algebras and partial O*-algebras. Then we summa
rize the representation theory of partial -algebras, including a gene
ralized Gel'fand-Naimark-Segal construction; the main tool here is the
notion of positive sesquilinear form, that we study in some detail (e
xtendability, normality, order structure,...). Finally we turn to auto
morphisms and derivations of partial O-algebras, and their mutual rel
ationship. The central theme here is to find conditions that guarantee
spatiality.