U. Jhala et Dl. Baly, EFFECT OF CHRONIC IL-1-BETA INFUSION ON GLUCOSE-HOMEOSTASIS AND PANCREATIC INSULIN-SECRETION, Life sciences, 54(6), 1994, pp. 413-422
Citations number
32
Categorie Soggetti
Biology,"Medicine, Research & Experimental","Pharmacology & Pharmacy
The present studies examined the effects of chronic interleukin-1 (IL-
1 beta) infusion on glucose homeostasis and insulin secretion in male
Sprague Dawley rats. IL-1 beta (4 mu g per day) or saline was infused
over a six day period using mini-osmotic pumps, surgically inserted un
der light ether anesthesia. Saline-infused rats were fed the amount of
food consumed by their respective pair in the IL-1 beta group on the
previous day. IL-1 beta infusion resulted in decreased food intake and
significant body weight loss as well as increased liver and kidney we
ights. IL-1 beta infusion resulted in fasting hypoglycemia as well as
elevated blood glucose levels in response to an oral glucose load comp
ared to controls. Glucose-induced insulin secretion from the isolated
perfused pancreas was significantly lower in IL-1 beta treated rats co
mpared to controls. These data demonstrate that chronic IL-1 beta admi
nistration alters glucose homeostasis and impairs glucose-induced insu
lin secretion.