PERSISTENCE OF FETAL HEMOGLOBIN PRODUCTION AFTER SUCCESSFUL TRANSPLANTATION OF CORD-BLOOD STEM-CELLS IN A PATIENT WITH SICKLE-CELL-ANEMIA

Authors
BRICHARD B VERMYLEN C NINANE J CORNU G
Citation
B. Brichard et al., PERSISTENCE OF FETAL HEMOGLOBIN PRODUCTION AFTER SUCCESSFUL TRANSPLANTATION OF CORD-BLOOD STEM-CELLS IN A PATIENT WITH SICKLE-CELL-ANEMIA, The Journal of pediatrics, 128(2), 1996, pp. 241-243
Citations number
12
Categorie Soggetti
Pediatrics
Journal title
The Journal of pediatrics → ACNP
ISSN journal
00223476
Volume
128
Issue
2
Year of publication
1996
Pages
241 - 243
Database
ISI
SICI code
0022-3476(1996)128:2<241:POFHPA>2.0.ZU;2-K
Abstract
A girl with sickle cell anemia was treated with cord blood transplanta tion combined with hematopoietic growth factor. Cord blood cells were collected from a sister with an identical human leukocyte antigen comp lex who was a carrier of the sickle cell trait (hemoglobin AS). The pa tient had complete engraftment and no graft-versus-host disease. The p ersistence of a high level of fetal hemoglobin 6 months after engraftm ent was noted.