PILOT-STUDY TO ASSESS THE EFFECT OF INHALED CORTICOSTEROIDS ON LUNG-FUNCTION IN PATIENTS WITH CYSTIC-FIBROSIS

Citation
Wh. Nikolaizik et Mh. Schoni, PILOT-STUDY TO ASSESS THE EFFECT OF INHALED CORTICOSTEROIDS ON LUNG-FUNCTION IN PATIENTS WITH CYSTIC-FIBROSIS, The Journal of pediatrics, 128(2), 1996, pp. 271-274
Citations number
12
Categorie Soggetti
Pediatrics
Journal title
ISSN journal
00223476
Volume
128
Issue
2
Year of publication
1996
Pages
271 - 274
Database
ISI
SICI code
0022-3476(1996)128:2<271:PTATEO>2.0.ZU;2-8
Abstract
Objective: To determine the effect of inhaled corticosteroids on lung function in patients with cystic fibrosis. Study design: We report a p ilot study of 49 patients with cystic fibrosis and moderate to severe bronchial obstruction (forced expiratory volume in 1 second less than or equal to 55% of the predicted value); 25 patients were given inhale d corticosteroids for 30 days (1500 mu g of beclomethasone via spacer) , and 24 patients had the same standard treatment but no inhaled corti costeroids. Results: Forced vital capacity, forced expiratory volume i n 1 second, and airway resistance showed significant improvement in bo th study groups, but thoracic gas volume and the diffusion capacity of the lung for carbon monoxide improved significantly only in the group given inhaled corticosteroids. When concomitant medications were take n into account, analysis of variance confirmed a significant effect of inhaled corticosteroids on the improvement of thoracic gas volume. Co nclusion: Inhaled corticosteroids in combination with standard treatme nt can contribute to the improvement of lung function in patients with cystic fibrosis and moderate to severe bronchial obstruction. Our pre liminary data seem encouraging enough to warrant a multicenter, long-t erm, blind control study.