Objective: To determine whether condom use among high-risk female adol
escents could be increased by a behavioral intervention, with the use
of infection with Chlamydia trachomatis as a biomarker of condom pract
ices. Design: Prospective, randomized, controlled intervention. Settin
g: Urban family planning and sexually transmitted disease clinics. Par
ticipants: Two hundred nine female adolescents, aged 15 through 19 yea
rs, who were treated for C. trachomatis genitourinary infection, were
randomly assigned to standard (control) or experimental (behavioral in
tervention) groups. One hundred twelve subjects returned for follow-up
5 to 7 months after enrollment and comprise the study subjects. Measu
rements: Subjects completed a multiinstrument questionnaire measuring
sexual behavior, condom practices, attitudes and beliefs, cognitive co
mplexity, sociodemographics, and motivation at enrollment and follow-u
p. Endourethral and endocervical sites were sampled for C. trachomatis
. Results: Among the 112 subjects who returned for repeated examinatio
n, those who had received the experimental intervention reported incre
ased use of condoms by their sexual partners for protection against se
xually transmitted diseases (odds ratio = 2.4; p = 0.02) and for vagin
al intercourse (odds ratio = 3.1; p = 0.005) at the 6-month follow-up.
Multivariable logistic regression analysis controlling for condom use
at enrollment demonstrated that the experimental intervention (odds r
atio = 2.8; p = 0.03) and the higher cognitive complexity (odds ratio
= 4.6; p = 0.02) independently contributed to greater condom use at fo
llow-up. Despite greater use of condoms among the group who had receiv
ed the intervention, use remained inconsistent and rates of reinfectio
n with C. trachomatis were not significantly different (26% vs 17%; p
= 0.3). Conclusion: Although a brief behavioral intervention among hig
h-risk female adolescents can increase condom use by their sexual part
ners, incident infection does not appear to be reduced, because condom
use remained inconsistent.