Je. Cox et al., INHIBITION OF SUCROSE INTAKE BY CONTINUOUS CELIAC, SUPERIOR MESENTERIC, AND INTRAVENOUS CCK-8 INFUSIONS, American journal of physiology. Regulatory, integrative and comparative physiology, 39(2), 1996, pp. 319-325
Two experiments compared the potency of continuous infusions of cholec
ystokinin octapeptide (CCK-8) for reducing sucrose intake when adminis
tered into abdominal arteries or the jugular vein. Adult, male Sprague
-Dawley rats received 22-min infusions of saline or several doses of C
CK-8. Sucrose was available for 20 min, beginning 2 min after onset of
infusions. In the first experiment, intraceliac CCK-8 in doses of 50,
125, and 312 ng produced significant reductions in intake, but no dos
e affected intake when administered into the jugular vein. In experime
nt 2, only the highest dose, 312 ng, suppressed intake when infused in
to the superior mesenteric artery, and jugular infusions were again in
effective. Behavioral observations indicated that intra-arterial CCK-8
had no affect on feeding within the first several minutes of test mea
ls but accelerated the subsequent decline in incidence of feeding. The
se results suggest that receptors involved in cholecystokinin satiety
are widely distributed within the gastrointestinal tract.