M. Gerova et al., EARLY CHANGES IN PROTEIN-SYNTHESIS IN EPICARDIAL CORONARY-ARTERY OF PRESSURE-OVERLOADED HEART, American journal of physiology. Heart and circulatory physiology, 39(2), 1996, pp. 685-691
In anesthetized dogs, a 4-h, similar to 30% increase in blood pressure
induced by constriction of the abdominal aorta brought about an incre
ase in the total RNA content in the left anterior descending coronary
artery (LADCA) and the left ventricular (LV) myocardium(9.05 +/- 1.72
and 11.06 +/- 4.68%, respectively) but not in the left circumflex coro
nary artery (LCCA). Under the same experimental conditions, [C-14]leuc
ine incorporation increased in LADCA and LV myocardium (45.34 +/- 13.5
4 and 58.07 +/- 11.91%, respectively), but not in LCCA. The data indic
ate an early shift in protein synthesis in LADCA and simultaneously in
the myocardium during a short-term presser event. The difference in t
he shift of protein synthesis in the two main branches of the left cor
onary artery was related to the quantitatively different deformation o
f the LADCA and LCCA due to different deformation of the underlying my
ocardium and/or of the annulus fibrosus atrioventricularis during chan
ges in the left or right ventricle volume [M. Gerova, E. Barta, M. Sto
larik, and J. Gero. Am. J. Physiol. 262 (Heart Circ. Physiol. 31): H10
49-H1053, 1992]. The results support the hypothesis that the deformati
on and/or rate of deformation of cells in the coronary wall may trigge
r an increase in protein synthesis. Changes in protein synthesis in th
e myocardium and LADCA were found to be reversible 2 h after releasing
the aortic constriction.