EFFECT OF SINGLE AND REPEATED DOSES OF A NEW NITRODERIVATIVE OF ACETYLSALICYLIC-ACID ON PLATELET TXA(2) PRODUCTION IN RATS

The effects of a new ASA-nitroderivative compound, NCX 4016 (ASA-NO2), on platelet TXA(2) synthesis after single and repeated doses in the r at were investigated. Compared to ASA, cumulative doses of ASA-NO2 sho wed similar inhibitory effects on platelet TXA(2) synthesis and signif icant increases in nitrite/nitrate plasma concentrations 1 h after the last drug administration: 24 h later nitrite/nitrate plasma levels re turned to the control values, while serum TXA(2) concentrations did no t change. A time-course study after a single dose of ASA-NO2 showed a significant inhibition of platelet TXA(2) production also 24 h after d rug administration and a significant increase in nitrite/nitrate plasm a levels until 10 h.