ANAL AND PENILE CONDYLOMAS IN HIV-NEGATIVE AND HIV-POSITIVE MEN - CLINICAL, HISTOLOGICAL AND VIROLOGICAL CHARACTERISTICS CORRELATED TO THERAPEUTIC OUTCOME

Clinical, histological and HPV DNA hybridization findings were analyze d for 73 homosexual and 38 heterosexual men attending for anal warts; therapy results were evaluated retrospectively for 76 of these patient s. Concurrent anal and penile warts occurred most commonly in the hete rosexual men (p<0.001), While perianal warts were most common in heter osexuals (p<0.05), intraanal warts were most common in homosexuals (p< 0.001). Altogether 23 homosexual men were HIV-infected; 13 HIV-positiv e men followed regarding therapeutic outcome were immunologically rela tively intact with mean CD4 counts of 524/mm(3). Of 136 biopsy specime ns 70% revealed benign hyperplasia, 27% AIN I, 2% AIN II and none AIN III. Of ISH positive samples 94% contained HPV 6/11 and 6% HPV 16/18/3 1/33. Anal warts were cured after an average of 2.5 (mean 1-10) therap y sessions in 64% of heterosexual, in 84% of HIV-negative homosexual a nd in 62% of HIV-positive homosexual men. The mean number of therapy s essions against anal warts was highest (p<0.001) and the time for acco mplishing cure for anal and penile warts was longest (p<0.001) in the heterosexual study group.