SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME ETHYL 2-AMINO ACETAMIDO-5-ARYLTHIOTHIAZOLE-4-CARBOXYLATES AND THEIR SULFONES - AN ATTEMPTED SYNTHESIS OF TAMIDO-[1]BENZOTHIOPYRANO[3,2-D]THIAZOL-9(H)-ONES/

Authors
BADDI MM MAHAJANSHETTI CS
Citation
Mm. Baddi et Cs. Mahajanshetti, SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME ETHYL 2-AMINO ACETAMIDO-5-ARYLTHIOTHIAZOLE-4-CARBOXYLATES AND THEIR SULFONES - AN ATTEMPTED SYNTHESIS OF TAMIDO-[1]BENZOTHIOPYRANO[3,2-D]THIAZOL-9(H)-ONES/, Indian journal of chemistry. Sect. B: organic chemistry, including medical chemistry, 35(3), 1996, pp. 233-237
Citations number
8
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Indian journal of chemistry. Sect. B: organic chemistry, including medical chemistry → ACNP
ISSN journal
03764699
Volume
35
Issue
3
Year of publication
1996
Pages
233 - 237
Database
ISI
SICI code
0376-4699(1996)35:3<233:SAAAOS>2.0.ZU;2-I
Abstract
The starting compounds ethyl -amino/acetamido-5-arylthiothiazole-4-car boxylates (4a-c and 5a-c) have been obtained by the reaction of ethyl 2-amino/acetamido-5-bromothiazole-4-carboxylates (1/2) with thiophenox ide anions 3a-c. Attempts to dehydrocyclise the acids obtained by the hydrolysis of 4a-c and 5a-c by PPA/H2SO4 to get the expected thioxanth ones are unsuccessful (9 - 11) since the ca:ion formed in the presence of acidic medium undergoes easy decarboxylation on heating. Compounds 6b and 7b have been found to show promising antibacterial and antifun gal activities.