TREATMENT OF CHANCROID WITH AZITHROMYCIN

A randomized, comparative study undertaken in Nairobi, Kenya and a non -comparative evaluation undertaken in Carletonville, South Africa have both shown that a single oral dose of azithromycin Ig is effective in the treatment of the genital ulcer disease (GUD), chancroid, with cur e rates of 89% and 92% recorded respectively. While treatment failure was associated with human immunodeficiency virus seropositivity and la ck of circumcision in Kenya, no such association could be found in the South African study. In both series, azithromycin treatment resulted in cure of both Haemophilus ducreyi culture-positive and culture-negat ive cases of GUD, including two cases subsequently diagnosed as lympho granuloma venereum. A combination of single-dose azithromycin with sin gle-dose benzathine penicillin may provide effective 'single-visit' sy ndromic treatment for GUD in many developing countries.