INHIBITOR SENSITIVITY OF RESPIRATORY COMPLEX-I IN HUMAN PLATELETS - APOSSIBLE BIOMARKER OF AGING

Authors
PICH MM BOVINA C FORMIGGINI G COMETTI GG GHELLI A CASTELLI GP GENOVA ML MARCHETTI M SEMERARO S LENAZ G
Citation
Mm. Pich et al., INHIBITOR SENSITIVITY OF RESPIRATORY COMPLEX-I IN HUMAN PLATELETS - APOSSIBLE BIOMARKER OF AGING, FEBS letters, 380(1-2), 1996, pp. 176-178
Citations number
22
Categorie Soggetti
Biophysics,Biology
Journal title
FEBS letters → ACNP
ISSN journal
00145793
Volume
380
Issue
1-2
Year of publication
1996
Pages
176 - 178
Database
ISI
SICI code
0014-5793(1996)380:1-2<176:ISORCI>2.0.ZU;2-D
Abstract
NADH-Coenzyme Q reductase was assayed in platelet mitochondrial membra nes obtained from 19 pools of two venous blood samples from female you ng (19-30 years) individuals and 18 pools from aged ones (66-107 years ). The enzyme activities were not significantly changed in the two gro ups, but a decrease of sensitivity to the specific inhibitor, rotenone , occurred in a substantial number of aged individuals, The results ar e in agreement with the predictions of the mitochondrial theory of age ing and may be used to develop a sensitive biomarker of the ageing pro cess.