PLASMA BETA-HEXOSAMINIDASE ISOENZYME-A AND ISOENZYME-B IN PATIENTS WITH CEREBRAL INFARCTION

Citation
B. Hultberg et al., PLASMA BETA-HEXOSAMINIDASE ISOENZYME-A AND ISOENZYME-B IN PATIENTS WITH CEREBRAL INFARCTION, Clinica chimica acta, 244(1), 1996, pp. 35-44
Citations number
19
Categorie Soggetti
Chemistry Medicinal",Biology
Journal title
ISSN journal
00098981
Volume
244
Issue
1
Year of publication
1996
Pages
35 - 44
Database
ISI
SICI code
0009-8981(1996)244:1<35:PBIAII>2.0.ZU;2-0
Abstract
We determined plasma activity of the isoenzymes of beta-hexosaminidase (Hex) in 151 patients with cerebral infarction, since earlier finding s have shown a relation between Hex isoenzymes and risk factors for va scular disease in normal subjects. Compared with 206 control subjects, an elevated level of plasma Hex isoenzymes was found in patients with cerebral infarction, particularly females. However, there was no rela tion to the clinical subtypes of diagnosis or to the presence of any r isk factors for vascular disease, such as carotid artery stenosis, maj or potential cardio-embolic risk factors on echocardiography, hyperten sion, heart disease, diabetes mellitus or tobacco smoking. Instead, ou r findings indicate that Hex isoenzymes in patients with cerebral infa rction are more influenced by the level of serum aspartate aminotransf erase and blood glucose. The main conclusion is that the liver functio n as reflected by the level of liver enzymes and glucose metabolism ar e the major determinants of Hex isoenzymes in plasma.