OXYTETRACYCLINE PRODUCTION BY STREPTOMYCES-RIMOSUS IN SOLID-STATE FERMENTATION OF CORN-COB

Corn-cob was used as a substrate in the production of oxytetracycline by Streptomyces rimosus TM-55 in a solid-state fermentation. Oxytetrac ycline was detected on day 4, and reached its maximum on day 8. Optima l conditions for oxytetracycline production were an initial pH of 5.2 to 6.3, an initial moisture content of 64% to 67%, supplementation wit h 20% (w/w) rice bran or 1.5% to 2.5% (w/w) (NH4)(2)SO4 as sole N sour ce, 1.0% (w/w) CaCO3, 2% (w/w) MgSO4.7H(2)O, and 0.5% (w/w) KH2PO4, wi th incubation for 8 days at 25 to 30 degrees C. Each g substrate produ ced 7 to 8 mg oxytetracycline.