COMPARISON OF CEFTRIAXONE VERSUS CEFOTAXIME FOR CHILDHOOD UPPER URINARY-TRACT INFECTIONS

It is very important to treat patients with upper urinary tract infect ions (UTIs) promptly and effectively because of the potential sequelae . In the present study we compare the efficacy of the two cephalospori ns, ceftriaxone and cefotaxime, in childhood pyelonephritis. The study protocal included 10 days of drug therapy. Both in patients receiving ceftriaxone and cefotaxime, successful eradication was achieved at th e second day of therapy. The overall cure rate was significantly bette r in the ceftriaxone group than the cefotaxime group in terms of recur rence and reinfections (p < 0.05). Furthermore, in the complicated gro up, ceftriaxone was slightly superior to cefotaxime, approaching signi ficance in terms of preventing recurrent infections. No serious advers e effects were observed in either of the groups. The present study has shown that ceftriaxone exhibits favorable clinical and bacteriologic efficacy in patients with complicated and uncomplicated upper UTI. Onc e-daily injection of ceftriaxone in children is also an attractive adv antage of the drug when compared to twice-daily cefotaxime.