A number of craniofacial malformation syndromes are characterized by p
rominent abnormalities of the skin, hair, nails, and mucous membranes,
Crouzon disease has been reported in association with severe acanthos
is nigricans in 12 patients. We report a new case of this association
in a 16-year-old woman with multiple melanocytic nevi, Melanocytic nev
i have been already reported in the medical literature in association
with several congenital syndromes, although, to our knowledge, not wit
h Crouzon disease.