CORONARY FLOW RESERVE - NONINVASIVE MEASUREMENT IN HUMANS WITH BREATH-HOLD VELOCITY-ENCODED CINE MR-IMAGING

PURPOSE: To measure coronary vasodilator reserve with breath-hold velo city-encoded cine magnetic resonance (MR) imaging. MATERIALS AND METHO DS: Eight healthy adult volunteers underwent 1.5-T MR imaging. Velocit y-encoded cine images were acquired at seven to 13 temporal phases in 25 seconds, with k-space segmentation and view-sharing reconstruction (+/-1 m/sec velocity-encoding value) (repetition time msec/echo time m sec 16/9). Flow velocity in the left anterior descending (LAD) artery was measured twice before and twice after administration of dipyridamo le (0.56 mg per kilogram of body weight). RESULTS: Peak diastolic coro nary flow velocity in the LAD artery was 14.8 cm/sec +/- 1.9 (mean +/- standard deviation) in the baseline state. IL increased significantly (P <.01) to 46.3 cm/sec +/- 10.2 after dipyridamole administration, w ith an average coronary reserve of 3.14 +/- 0.59. Interstudy and inter observer reproducibilities for measurement of peak diastolic velocity were, respectively, 9.5% +/- 1.6 and 7.0% +/- .2.5 in the baseline sta te and 6.8% +/- 2.2 and 3.4% +/- 1.5 after dipyridamole administration . CONCLUSION: Breath-hold velocity-encoded cine MR imaging provided re producible assessment of coronary flow reserve in humans.