KINETIC-STUDY OF BROMESULPHONEPHTHALEIN A ND INDOCYANINE GREEN IN DUCKS - EVALUATION OF LINEARITY

Pharmacokinetics of bromosulphonephthalein ( BSP) and indocyanine gree n (ICG) were determined at different doses in 14 weeks old mullard duc ks. The doses were 4, 7, 10, and 14 mg/kg for BSP and 0.25, 0.5, 0.74 and 1 mg/kg for ICG of body weight. Birds were given BSP and ICG intra venously with a two week-washout period between treatments. Relationsh ip between administered doses and some pharmacokinetics variables ( in itial concentrations, volumes of distribution, area under the curves) was linear. This study proved that doses between 7 and 15 mg/kg for BS P and 0.5 and 1 mg/kg for ICG are suitable for assessing hepatic uptak e-elimination function in ducks.