HYPERPLASIA OF THE THYROID-GLAND AND CONCURRENT MUSCULOSKELETAL DEFORMITIES IN WESTERN CANADIAN FOALS - REEXAMINATION OF A PREVIOUSLY DESCRIBED SYNDROME
Al. Allen et al., HYPERPLASIA OF THE THYROID-GLAND AND CONCURRENT MUSCULOSKELETAL DEFORMITIES IN WESTERN CANADIAN FOALS - REEXAMINATION OF A PREVIOUSLY DESCRIBED SYNDROME, Canadian veterinary journal, 35(1), 1994, pp. 31-38
A syndrome of neonatal foals characterized by hyperplasia of the thyro
id gland and concurrent musculoskeletal deformities (TH-MSD) has been
described in western Canada and may be increasing in incidence. In an
attempt to improve recognition and understanding of this syndrome, 294
6 records of equine abortuses, stillborns, and dead neonatal foals wer
e examined to determine the laboratory involved, the year and month of
submission, the breed and sex of the fetus or foal, the type of perin
atal loss, the length of gestation, and whether or not the submission
had evidence of a lesion of the thyroid gland, the musculoskeletal sys
tem, or other abnormal clinical or postmortem findings. One hundred an
d fifty-four (5.2%) records indicated the presence of an abnormal thyr
oid gland. Of these, 79 (2.7%) had additional lesions consistent with
the TH-MSD syndrome described in the 1980s, while 75 (2.5%) were witho
ut these additional lesions. Comparisons among these two groups and a
third group of fetuses and foals without lesions of the thyroid glands
are described. The results confirm that the TH-MSD syndrome is a spec
ific and unique disease with no breed or sex predilection. It is argue
d that there may be an ''exposure-related'' cause, and based on a revi
ew of similar disease syndromes of the horse, it is suggested that an
examination of the feed is indicated in outbreaks of the TH-MSD syndro
me.