Compliance in antiasthmatic, especially antiinflammatory therapy is ge
nerally critical. Despite the knowledge on hundreds of documented comp
liance correlates, the understanding of the process character of treat
ment motivation and compliance requires further clarification. Within
the context of the patient's coping with asthma, the paper outlines pr
ototypical feedback loops leading to stable versus insufficient compli
ance patterns during the course of the chronic disease. Compliance dif
ficulties may be part of the following vicious circle: a high severity
of disease in the individual implies a broad array of somatic and psy
chosocial stressors which may intensify experiences of threat and help
lessness, especially in the case of insufficient coping resources. Cop
ing behavior then tends to be occupied by emotion regulation instead o
f problem solving which results in continuous deficits in asthma manag
ement. The lack of self-efficacy experiences further reduces treatment
motivation and adherence behavior which, in turn, increases the risk
of additional exacerbations and, therefore, the severity of asthma in
the patient. The worsened prognosis finally enlarges the patient's str
ess level which again may impede succeesful coping and adequate compli
ance. As a counterpart, a positive circle of ongoing compliance stabil
ization is outlined as well.