Baker's asthma belongs to the classical type I allergic reactions. Dif
ferent cereal flours, particularly wheal flour, are accused to initiat
e this disease. Beside water-soluble flour proteins of low molecular w
eight, amylase inhibitors are regarded to be the major allergens in ba
ker's disease. Furthermore, some baking additives have to be mentioned
as important allergens. The additive alpha-amylase, originating from
Aspergillus oryzae, is the best known allergen being well established
in routine diagnostic procedures.