A CASE OF HYPERGONADOTROPHINAEMIA ASSOCIATED WITH VERY HIGH ISOLATED CONCENTRATIONS OF IMMUNOLOGICALLY AND BIOLOGICALLY-ACTIVE LUTEINIZING-HORMONE

A very rare case of a menstruating infertile woman with isolated lutei nizing hormone (LH) hypergonadotrophinaemia is presented, There were n o signs indicating the presence of a pituitary microadenoma, and LH ha d normal bioactivity and normal molecular weight, Likewise, no mutatio n was detected in the coding region of the LH beta-chain gene, In a no n-stimulated cycle and a clomiphene citrate cycle, the patient develop ed an unruptured cyst, The patient ovulated and conceived twice follow ing the addition of human chorionic gonadotrophin, A partial resistanc e at the ovarian LH receptor site, perhaps caused by a mutation, is a possible explanation for these findings, Another possibility is a malf unction in the signal transduction system of LH beyond the receptor le vel.